siRNA succesful as therapeutics in primates

A new Nature paper shows that systemic delivery of siRNAs against ApoB actually works.
The siRNAs are delivered in liposomes. The treatment reduced blood levels of ApoB-100 protein, total cholesterol and LDL.

The authors did several test for toxicity of the treatment and found no ill effects.

This could well revolutionize drug therapy and fulfill the promise about gene directed interventions that earlier attempts at gene therapy have failed to give.